侵袭性A型 estreptococcal感染:从2022-2023年的暴发中吸取的教训
Alix Flamant1, Alicia Demirjian2, Theresa Lamagni3
1Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France.
The Lancet. Infectious diseases
|July 12, 2025
概括
在COVID-19后,特别是在儿童中,侵袭性A组链球菌 (iGAS) 感染的增加被观察到. 本综述检查了流行病影响,病毒共感染和细菌进化作为这种增加的潜在原因.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 微生物学 微生物学
背景情况:
- 几个高收入国家在COVID-19大流行后期观察到侵袭性A型 estreptococcal (iGAS) 感染的显著增加.
- 这一激增与相当大的发病率和死亡率有关,特别是在儿科患者群体中.
研究的目的:
- 审查可能导致iGAS感染增加的因素.
- 探索COVID-19大流行和非药物干预 (NPI) 对A组链球菌 (GAS) 循环的影响.
- 调查其他呼吸道病毒和高病毒性GAS菌株的作用.
主要方法:
- 文献综述综合了iGAS流行病学的数据.
- 分析COVID-19,NPI和GAS传输动态之间的相互作用.
- 检查分子流行病学和GAS的进化趋势.
主要成果:
- 由于COVID-19大流行和相关的NPI,可能已经改变了GAS循环模式.
- 与其他呼吸道病毒如流感和RSV的同时感染可能会加剧IGAS疾病.
- 高病毒性GAS克隆的出现或增加的患病率可能会导致观察到的激增.
结论:
- iGAS疾病的复苏需要加强对侵入性和非侵入性GAS感染的监测.
- 进一步的研究对于了解宿主免疫力,病毒相互作用和细菌进化的作用至关重要.
- 为了制定有效的公共卫生策略来对抗iGAS疾病,全面的了解至关重要.
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