联合物理和认知干预对老年痴呆症患者的影响:系统审查和元分析
Dandan Xue1, Yanqiu Hu2, Rui Zhang3
1Department of Nursing, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Journal of the American Medical Directors Association
|July 12, 2025
概括
联合体力和认知干预显著改善了痴呆症患者 (PwD) 的结果,包括认知,移动性和生活质量. 然而,它们并没有比单个干预单独提供更大的好处.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
背景情况:
- 身体和认知干预有益于痴呆症患者 (PwD).
- 对PWD联合干预的证据是不一致的.
- 现有的审查缺乏联合干预和单一干预之间的直接比较.
研究的目的:
- 综合PWD联合物理和认知干预的证据.
- 将组合干预与单个干预 (仅仅是物理或认知) 进行比较.
- 评估对认知,身体,心理,功能和HRQoL结果的影响.
主要方法:
- 对23项研究进行了系统审查和元分析.
- 包括1716名老年痴呆症患者.
- 在8个数据库中进行搜索;使用Cochrane偏差风险工具进行质量评估;用于元分析的随机效应模型.
主要成果:
- 与对照组相比,联合干预显著改善了全球认知 (SMD,0.65),处理速度 (SMD,0.33),功能移动性 (SMD,0.85),力量 (SMD,0.95),抑郁 (SMD,-1.04),和HRQoL (SMD,0.71).
- 与单个干预相比,总体效益没有显著差异.
- 对全球认知的有效性因参与者的年龄而异.
结论:
- 综合干预有效地提高了PWD的认知,身体,心理和HRQoL结果.
- 建议将其纳入痴呆症管理协议.
- 未来的研究应该使用多臂RCT进行直接比较和长期可持续性研究.
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