在患有喘的儿童中,从螺旋计参考方程中删除种族的含义
Lina Z Mahmood1, Tamara T Perry2, Akilah A Jefferson2
1Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas.
概括
全球肺部倡议 (GLI) -2022方程影响儿童喘评估. 它可能会在非洲裔美国人和拉丁裔儿童中揭示更多未被确诊的喘,从而有可能减少健康差异.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 健康差距 研究 研究 研究 研究
背景情况:
- 全球肺部倡议 (GLI) 在2022年引入了一种种族中立的参考方程 (GLI-2022).
- GLI-2022对不同儿科群体,特别是拉丁裔儿童的喘评估的影响仍未得到充分研究.
研究的目的:
- 在GLI-2022实施后,评估螺旋测量结果,喘严重程度和呼吸道阻塞分类在非洲裔美国人 (AA),拉丁裔和白人的喘儿童的变化.
- 将GLI-2022的发现与以前的赛事调整后的GLI-2012方程进行比较.
主要方法:
- 对5至17岁患有喘的儿童 (2018-2023) 的螺旋计数据进行了回顾性横截面分析.
- 使用GLI-2022和GLI-2012方程计算FVC,FEV1和FEV1/FVC的z-score和百分比预测值.
- 包括7138名儿童:3543名AA,2795名白人和800名拉丁裔.
主要成果:
- GLI-2022的实施显示了FEV1z分数的显著差异:AA为-0.872,拉丁裔为-0.360,白人为+0.267 (P < .0001).
- 喘严重程度和呼吸道阻塞分类在AA儿童中恶化,在白人儿童中改善.
- 拉丁裔儿童的分类基本上没有受到影响,但与白人儿童相比,FVC和FEV1值较低.
结论:
- GLI-2022的采用改变了跨种族群体的喘严重程度和阻塞分类.
- 新的方程式可能会导致在AA和拉丁裔儿童中发现更多未被确诊的喘病例.
- 这可能是解决和缓解喘结果差异的关键一步.
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