在心房的患者中,年龄和左心房功能障碍的相关性
Jackson O Howie1, Jenelle K Dziano1, Jonathan P Ariyaratnam1
1Centre for Heart Rhythm Disorders, University of Adelaide, South Australian Health and Medical Research Institute and Royal Adelaide Hospital, Adelaide, Australia.
Heart rhythm
|July 12, 2025
概括
随着年龄的增长,心房动 (AF) 患者的左心房 (LA) 功能和结构恶化,导致运动能力受损. 这些与年龄相关的变化表明更先进的LA疾病,影响心力衰竭与保存的射出分数风险.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 电子生理学 电子生理学
背景情况:
- 保持喷射分数 (HFpEF) 的心力衰竭在心房动 (AF) 中很普遍,通常来自左心房 (LA) 心肌病.
- 年龄增长是AF患者发展LA心肌病和HFpEF的重要风险因素.
研究的目的:
- 研究老龄化对LA结构和功能的侵入性和非侵入性指标在症状性AF患者中的影响.
- 为了将与年龄相关的LA变化与功能能力和患者报告的症状相关联.
主要方法:
- 在导管切除过程中进行的侵入性血液动力学评估量化了125名具有症状的AF患者的LA压力和硬度,这些患者的LV功能被保留.
- 非侵入性评估包括LA菌株和体积,LV菌株和体积,尿酸,心肺运动测试和症状问卷.
- 对常见风险因素进行调整的统计分析,以确定与年龄相关的关联.
主要成果:
- 年龄的增加与LA压力和硬度的升高相关,65岁以上的患者有明显的LA硬度.
- 年龄与减少的LA储压力,增加的LA体积,减少的LV终端-透析体积和增加的尿素有关.
- 年龄较大与氧气消耗峰值降低有关,这表明运动不耐受,但没有AF严重程度或HF症状.
结论:
- 在症状性AF患者中,衰老与左心房的显著血动力学,结构和功能障碍有关.
- 这些与年龄相关的LA变化表明LA疾病的进展,并导致运动不耐受.
- 虽然年龄会影响LA功能和运动能力,但在这个队列中,它与患者报告的心力衰竭症状没有直接相关.
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