通过抗体结合到膜-近端纤维蛋白3型域的PTPRS蛋白质糖开关的调节

Thales Hein Da Rosa1, Sterling H Ramsey2, Judy J Lee1

  • 1Department of Medicine, Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

概括

针对受体蛋白氨酸酸酶西格玛 (PTPRS) 的纤维素第III类类似9 (Fn9) 域,激活了它的功能. 这种使用抗体或诱蛋白的方法,通过减轻小鼠的疾病来治疗类风湿性关节炎 (RA) 是有前途的.

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