氧通过诱导斑马鱼 (Danio rerio) 的线粒体功能障碍和氧化应激引起心血管毒性和神经行为异常
Xiaoting Man1, Yiwei Du1, Heyang Guo2
1College of Life Science, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Environmental research
|July 12, 2025
概括
氧 (PCMX) 破坏斑马鱼的发育,导致心脏缺陷和神经行为问题. 这种抗菌剂损害了线粒体功能,增加了氧化应激,并引发细胞死亡,突出显示了水生生物的风险.
科学领域:
- 环境毒理学环境毒理学
- 发育生物学是发展生物学.
- 水生物质毒理学研究
背景情况:
- 氧 (PCMX) 是一种在水体中广泛使用的抗菌剂.
- 其对生态和健康的风险,特别是对水生生物的风险,尚不清楚.
研究的目的:
- 研究PCMX对斑马鱼胚胎发育,心血管系统和神经行为的有毒影响.
- 阐明PCMX毒性的潜在分子机制.
主要方法:
- 斑马鱼胚胎在受精后120小时内暴露在各种PCMX度 (010 mg/L) 中.
- 评估胚胎发育,化率,形态异常,心脏功能和神经行为.
- 分析了与心血管发育,线粒体呼吸,氧化应激和信号传递相关的基因表达.
主要成果:
- 暴露于PCMX会降低发育速度,延迟化,并诱导斑马鱼胚胎的形态异常.
- 观察到显著的心血管缺陷和心脏功能受损,与心血管基因表达失调有关.
- 线粒体功能障碍,过度反应性氧物种 (ROS) 生产,氧化应激增加和通过线粒体通路的亡被确定为关键机制.
- 信号通路的破坏也与PCMX诱导的心脏毒性有关.
结论:
- 在斑马鱼胚胎中,PCMX诱导了显著的发育,心血管和神经行为毒性.
- 线粒体功能障碍,氧化应激,亡和信号破坏是PCMX毒性的关键机制.
- 研究结果强调了PCMX在水生环境中的潜在生态风险及其对人类健康的影响.
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