患有囊性纤维化儿童和青少年的骨矿物质密度:一项纵向研究
G Tamer1, H M van Santen2, Hgm Arets3
1Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands.
患有囊性纤维化 (CF) 的儿童的骨矿物质密度 (BMD) 随着时间的推移而降低,特别是在男孩和患有新发性囊性纤维化相关糖尿病 (CFRD) 的儿童中. 在儿科CF患者中早期监测BMD至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 囊性纤维化研究 囊性纤维化研究
背景情况:
- 患有囊性纤维化 (CF) 的成年人患骨质疏松率高于健康成年人.
- 最佳的骨质积累始于童年.
- 了解CF的儿科骨健康对于长期结果至关重要.
研究的目的:
- 评估患有CF的青少年骨矿物质密度 (BMD) 降低的患病率.
- 在这个人群中随着时间的推移跟踪BMD的变化.
- 为了确定与儿童CF患者骨硬化率降低相关的风险因素.
主要方法:
- 106名患有CF的儿童和青少年接受了人体测量,双能X射线吸收测量 (DXA) 和内分泌评估.
- 骨矿物质密度Z-分数是高度调整的.
- 多变量分析检查了65名具有串行DXA数据的患者的BMDZ分数的变化.
主要成果:
- 虽然BMD中位数Z-score在基线正常,但随着时间的推移,在腰椎和全身减头 (TBLH) 观察到显著下降.
- 在男孩中,TBLH BMD Z-分数的下降更为明显.
- 新发性囊性纤维化相关糖尿病 (CFRD) 是TBLH BMD Z-score变化的显著负预测因素.
结论:
- 大多数患有CF的儿童和青少年最初表现出正常的BMD Z-分数.
- 在儿童和青少年时期,BMD Z-score的显著下降发生.
- 男孩和新诊断的CFRD患者有更高的骨髓损失风险.
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