怀孕期间母亲的血压和儿童的心脏代谢功能:一个出生队列研究
Hualong Zhen1, Lu Chen1, Xuemei Hao1
1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Environment and population Health across the Life Course, Hefei, 230032, China.
概括
孕妇在怀孕期间的高血压 (BP),特别是在第二和第三季度,与儿童心脏代谢健康状况较差有关. 系统性BP轨迹对后代产生了显著的影响.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 心脏病学 心脏病学
背景情况:
- 关于妊娠期间血压 (BP) 轨迹如何影响儿童心脏代谢风险 (CMR) 的证据有限.
- 了解这种关系对于早期干预和预防策略至关重要.
研究的目的:
- 调查每三个月的母体血压和妊娠期间的整体血压轨迹与后代的心脏代谢功能之间的关联.
- 确定对儿童心脏代谢健康最有影响的特定三季度和血压参数.
主要方法:
- 分析了来自马安山出生队伍的2,159对母婴对.
- 母亲血压在产前测量;儿童心脏代谢生物标志物在4-6岁时评估.
- 用于分析数据的线性和通用线性模型.
主要成果:
- 妊娠第一季度母亲的血压主要影响了儿童的血压.
- 第二和第三个月的母亲血压影响了儿童的总CMR,包括葡萄糖,脂质代谢和血压.
- 母亲高血压轨迹,特别是缩血压 (SBP),与后代增加的CMR相关. 妊娠的高血压疾病也与更高的后代CMR有关.
结论:
- 怀孕期间母亲血压升高,特别是在晚期的三个月,可能预测后代的不良心脏代谢健康状况.
- 孕产妇SBP似乎对儿童的心脏代谢产生更大的影响,而不是透静血压.
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