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Updated: Jul 15, 2026

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不同的B细胞消耗策略对淋巴组织的影响

Carlo Tur1, Markus Eckstein2, Laura Bucci3

  • 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany; Division of Rheumatology-Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.

Annals of the rheumatic diseases
|July 12, 2025
PubMed
概括

基于蛋白质的B细胞枯竭疗法,包括奥比努祖马布和布利纳图莫马布,在自身免疫性疾病的淋巴结内枯竭B细胞方面表现出有限的疗效. 完全的B细胞枯竭和卵泡结构破坏主要观察到CD19仿真抗原受体T细胞治疗.

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