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Updated: Sep 15, 2025

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
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细胞内病原体效应因子通过抑制mRNA衰变来重新编程宿主基因表达.

Yevgen Levdansky1, Justin C Deme1, David J Turner1

  • 1National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Nature communications
|July 12, 2025
PubMed
概括

细菌病原体Legionella pneumophila使用其效应因子PieF通过准CCR4-NOT死亡酶复合体来阻止宿主mRNA衰变. 这种新的机制抑制了死化,影响了宿主细胞周期的进展.

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Cis-acting Elements involved in mRNA stability
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Nonsense-mediated mRNA Decay

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Nuclear Export of mRNA

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Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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