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Updated: Sep 15, 2025

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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Published on: January 29, 2018

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没有氨酸的瘤抑制剂p14ARF的SUMOylation可以抵消依赖于无处不在的降解

Ahmed El Motiam1,2,3, Yanis H Bouzaher4, Haifen Chen5

  • 1Centro de Investigación en Medicina Molecular (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain. elmotiam@lunenfeld.ca.

Cell death & disease
|July 12, 2025
PubMed
概括

瘤抑制剂p14ARF在其N端被SUMOylated,这使其稳定,防止退化. 抑制NEDDylation可以提高SUMOylation和p14ARF水平,从而影响前列腺癌细胞的细胞毒性.

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