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Updated: Sep 15, 2025

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity
09:21

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

Published on: October 22, 2018

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在酵母细胞壁应激的适应性反应期间,合成速率和mRNA稳定性的全球变化

José García-Martínez1, Jose M Rodríguez-Peña2, José E Pérez-Ortín1

  • 1Instituto de Biotecnología y Biomedicina (BIOTECMED), Facultad de Biológicas, Universitat de València, C/Dr. Moliner 50, Burjassot, E46100, Spain.

Scientific reports
|July 12, 2025
PubMed
概括

酵母细胞壁的压力主要通过减少合成而不是稳定性来影响mRNA水平. 新发现揭示了特定的基因通过增加合成和稳定性来积累mRNA,突出显示了转录后缓冲机制.

关键词:
细胞壁完整性通路 细胞壁完整性通路细胞壁应力压力是什么环境压力反应环境压力反应基因组运行启动在MRNA的稳定性.转录 翻译 翻译

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