基于微针贴片的纳洛通过鼻子输送纳洛
Akeemat Tijani1, Carmine Schiavone2,3, Prashant Dogra3,4
1Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, 37614, USA.
Drug delivery and translational research
|July 12, 2025
概括
溶解微针 (MN) 贴片为纳洛 (NAL) 输送提供了一种新的方法,比通过皮肤的方法显著更高的透鼻透率. 这项技术为有效的阿片类药物过量治疗提供了持续的NAL输送.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 传统的纳洛 (NAL) 鼻内喷雾剂需要经常重新剂量,特别是长效阿片类药物.
- 通过皮肤输送的NAL在有效性和吸收率方面存在局限性.
- 治疗阿片类药物过量需要有效和快速的NAL管理.
研究的目的:
- 为了评估溶解微针 (MN) 贴片用于过鼻性纳洛 (NAL) 输送.
- 为了比较MN贴片的疗效与通过皮肤和常规鼻内NAL输送的疗效.
- 优化MN补丁设计,以实现持续和高效的NAL透.
主要方法:
- 在猪鼻腔粘膜上制造和测试聚烯利 (PVP) 和PVP/Chitosan MN贴片.
- 在1小时和24小时内累积NAL透的量化,用于跨鼻和通过皮肤输送.
- 数学建模以模拟药物溶解,透动力学和血度动力学.
主要成果:
- 通过鼻腔的MN贴片显示,与通过皮肤的应用相比,1小时和24小时的累积NAL透率显著更高.
- 在PVP MN补丁中,比通过皮肤 (103 μg/cm2) 进行的超级透 (7295.12 μg/cm2) 超过1小时的透.
- 当药物装载在MN尖端和底部时,观察到持续的输送,而不是只有尖端的装载.
结论:
- 溶解的MN贴片提供了一个可行的,持续的纳洛 (NAL) 经鼻输送系统.
- 这项技术为有效的阿片类药物过量治疗提供了一个有希望的替代方案,可能会减少再剂量频率.
- 优化的MN贴片设计可以实现与现有给药途径相比较的治疗性血配置文件.
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