父亲和母亲对和多基物质 (PFAS) 的暴露以及出生结果:一项多国队列研究

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Pengfei Guo^1,2, Jiajun Luo^3,4, Jie Zhang⁵

¹Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, CT, 06510, New Haven, USA.

Environmental health : a global access science source

|July 12, 2025

概括

孕产妇暴露在 perfluorooctanoate (PFOA) 中可能与较低的出生体重有关,而父亲暴露在 per-和多基基物质 (PFAS) 中可能与后代的出生时间较短有关. 需要对母公司特定的PFAS影响进行进一步的研究.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
儿科健康儿科健康

背景情况:

孕产妇暴露于和多基物质 (PFAS) 与不良出生结果有关.
关于父 PFAS 暴露及其对后代的影响的研究有限.
这项研究调查了产前PFAS暴露和出生结果之间的父母特异性关联.

研究的目的:

检查产前PFAS暴露与妊娠年龄,出生体重和出生长度的父母特定关联.
评估母亲和父亲的PFAS暴露对不良分娩结果的影响.
探索母亲和父亲对PFAS暴露的影响的潜在差异.

主要方法:

包括来自INUENDO队列的498对夫妇 (格陵兰,波兰,乌克兰,2002-2004).
在怀孕期间在父母血清中测量了五种主要的PFAS类型.
分析了血清PFAS和出生结果之间的关联,使用加权最小方程回归和量子式g计算.

主要成果:

没有发现母亲/父亲的PFAS和妊娠年龄之间的关联.
经过对父亲的PFOA进行调整后,与较低出生体重和较短出生长度的趋势相关的母体 perfluorooctanoate (PFOA) 暴露.
父亲的PFAS暴露显示出较短出生时间的趋势,效果大小小.

结论:

母亲的PFOA和父亲的PFAS暴露可能与分别较低的后代出生体重和较短的出生时间有关.
有证据表明,PFAS对后代生长的潜在父母特异性影响.
需要进一步的研究来阐明父母特定的PFAS暴露在儿童发育中的作用.

关键词:

出生后的结果.内分泌干扰物干扰内分泌干扰物环境污染物环境污染物在PFAS中,我们可以使用PFAS.父亲暴露的情况.怀孕怀孕怀孕怀孕

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