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Updated: Sep 15, 2025

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抗菌的α-螺旋结构通过分子表面特征增强了它们的活性

Michael Quagliata1, Joshua Grabeck2, Kathrin König3

  • 1Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, I-50019 Sesto Fiorentino, Italy.

Biochemistry
|July 13, 2025
PubMed
概括

通过采用结构化的α-螺旋形状,triazolyl桥接体表现出增强的抗菌活性. 这种结构优化了电荷和残留物分布,改善了与细菌膜的相互作用,以对抗耐药性病原体.

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