Limosilactobacillus reuteri改善了完全受影响的牙提取后的愈合:随机临床试验
Chiara Cinquini1,2, Rossana Izzetti1, Marco Nisi1
1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Oral diseases
|July 13, 2025
概括
补充Limosilactobacillus reuteri (L. reuteri) 补充剂改善了伤口愈合,并在冲击牙提取后减少了三. 患者报告说,使用益生菌的结果更好,功能障碍更少.
科学领域:
- 在口腔外科手术中.
- 微生物学 微生物学
- 临床试验中的临床试验.
背景情况:
- 该研究协议已在Clinicaltrials.gov (NCT04903925) 上注册.
- 冲击牙提取后的术后结果可以通过有针对性的干预措施来改善.
- 利莫西拉克托巴西勒 (Limosilactobacillus reuteri) 是一种具有潜在免疫调节作用的益生菌.
研究的目的:
- 评估Limosilactobacillus reuteri (L. reuteri) 在增强术后伤口愈合方面的疗效.
- 评估L. reuteri对疼痛水平和受影响牙拔除后患者报告结果 (PROs) 的影响.
- 为了研究L. reuteri对三症和手术提取后功能障碍的影响.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 经过手术提取的128名患者随机分配每天接受L. reuteri或安慰剂.
- 包括伤口愈合,疼痛,三症和口腔健康影响概况-14 (OHIP-14) 在外科手术后的3,7和14天进行了评估.
主要成果:
- 在手术后3天和7天,L. reuteri显著改善了伤口愈合.
- 益生菌组在3天和14天经历了较轻微的三症,并且减少了功能障碍.
- 没有观察到疼痛的显著差异,但L. reuteri组在14天后的OHIP-14得分较低,使用的抗炎药物较少.
结论:
- Limosilactobacillus reuteri的使用对伤口愈合有积极的影响,并减少了受冲击的牙提取后的三症的严重程度.
- 补充L. reuteri与患者报告的结果有所改善,包括功能障碍减少.
- 益生菌的使用可能是一个有益的辅助疗法,以优化手术牙科手术后的恢复.
相关概念视频
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
178
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
178
01:26Tonsillitis II: Management
178
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
178
01:21Drugs for Treatment of Constipation-Predominant IBS
347
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
347