临床病理学特征与肺癌中PET/CT吸收之间的关系:[18F]FAPI与[18F]FDG
Kailin Qiao1, Tao Zhou2, Yinjun Dong3
1Department of Radiation Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
这项研究表明,肺癌中[F]纤维细胞激活蛋白抑制剂 (FAPI) 的吸收与临床阶段和组织学相关,与[F]氧糖 (FDG) 的吸收不同. 这些发现提供了对肺癌特征的更细致的理解.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 无线电学 (Radiomics) 是一种无线电学.
背景情况:
- 肺癌表现出不同的临床病理特征.
- 使用氧糖 (FDG) 的正子发射断层扫描/计算机断层扫描 (PET/CT) 是一种标准的成像方法.
- [18F]纤维细胞激活蛋白抑制剂 (FAPI) PET/CT是一种新兴的癌症成像追踪器.
研究的目的:
- 调查原发性肺癌中[FAPI]和[FDG]吸收参数之间的关系.
- 为了将这些成像参数与肺癌患者的各种临床病理特征相关联.
主要方法:
- 一项涉及62名肺癌患者的前性试验的二次分析.
- 配对FAPI和FDGPET/CT扫描在7天的时间间隔内进行.
- 进行了统计分析,以比较不同临床阶段的成像参数,组织学类型,PD-L1 TPS和Ki-67分数.
主要成果:
- [18F]FAPI吸收 (SUVmax,SUVpeak,TBR) 在临床阶段和组织学类型 (p <0.05) 中显示出显著差异.
- [18F]FDG摄入量在这些组之间没有显著差异 (p>0.05).
- 较低的PD-L1 TPS (<1%) 与较高的FAPI激活瘤体积 (FTV) 和较高的FDG代谢瘤体积 (MTV) 相关.
- 更高的Ki-67分数 (≥50%) 与增加的FDG吸收相关 (SUVmax,SUVpeak,TLG).
结论:
- [F]FAPI和[F]FDG PET/CT反映了肺癌中不同的临床病理特征.
- [F]FAPI吸收与瘤阶段和组织学有关.
- [18F]FDG吸收与瘤增殖标志物如Ki-67和PD-L1状态更密切相关.
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