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基于闪光灯屏幕的紧质子放射学系统的可行性研究

Francesco Olivari¹, Marc-Jan van Goethem¹, Sytze Brandenburg¹

¹Department of Radiation Oncology, University Medical Centre Groningen (UMCG), University of Groningen (RUG), Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|July 13, 2025

概括

质子放射学的目标是1%的精度在水等效路径长度 (WEPL) 确定质子疗法. 一个实验系统在20毫米和40毫米的样本中分别达到1.6%和0.7%的准确性,对于1%的目标需要优化.

科学领域:

医学物理医学物理
放射性成像学成像学
辐射瘤学辐射瘤学

背景情况:

质子疗法提供精确的剂量输送,但面临着各种不确定性.
精确的水等价路径长度 (WEPL) 确定对于减轻这些不确定性至关重要.
质子放射是实现必要的WEPL精度的一个有前途的技术.

研究的目的:

实验验证一个单一的二维探测器系统用于质子放射学.
评估系统在WEPL和相对制动功率 (RSP) 测量中达到1%准确度的能力.
使用20毫米和40毫米的水等效样本在140 MeV光束能量下测试系统.

主要方法:

使用闪屏幕与CCD摄像系统相结合.
用140 MeV的质子束对同质样本进行辐射.
测量发射光 (探测器响应) 和模拟质子流动,以得出WEPL和RSP分布.

主要成果:

获得的平均一致性为1.6%的20毫米样本和0.7%的40毫米样本之间的衍生和参考WEPL/RSP.
鉴定了闪光屏的光输出波动是实现更高精度的主要限制.
在严格的测试条件下证明了系统的潜力.

结论:

实验系统没有达到在严格条件下确定WEPL的1%准确度的目标.
相对于样本WEPL,优化质子束能量可能是实现所需精度的关键.
进一步的开发可能使质子放射学能够显著提高质子疗法范围的准确性.

关键词:

质子辐射学质子辐射学相对制动功率 (RSP) 是指相对制动功率.闪屏幕与CCD摄像机相结合.

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