在高脂肪饮食下环境度的抗生素暴露:对肠道微生物群和新陈代谢的影响
Liang Zhao1, Jian Xu1, Xiaowei Li1
1State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
环境抗生素,如阿齐思罗米和西普罗夫洛克萨改变肠道微生物和新陈代谢,特别是高脂肪饮食. 这些变化会影响微生物群落,短链脂肪酸和宿主健康.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 毒理学 毒理学 毒理学
背景情况:
- 抗生素是广泛存在的环境污染物,导致人类不可避免的暴露.
- 高脂肪饮食 (HFD) 显著影响肠道微生物群和宿主新陈代谢.
- 低剂量抗生素和HFD对肠道健康的联合影响尚未完全理解.
研究的目的:
- 调查环境相关度的阿齐思罗米 (AZI) 和西普罗洛克萨 (CIP) 对肠道微生物群和宿主代谢的影响.
- 评估在高脂肪饮食 (HFD) 维持的小鼠中这些影响.
- 探索微生物群落结构,短链脂肪酸 (SCFA) 概况和宿主代谢参数的变化.
主要方法:
- 通过饮用水向小鼠注射微量AZI和CIP.
- 在研究期间,小鼠一直吃高脂肪饮食 (HFD).
- 分析包括肠道微生物社区结构,SCFA概况,血清激素水平和血清代谢概况.
主要成果:
- 长期暴露于微量抗生素显著改变了肠道微生物社区结构.
- 在男性和女性中,AZI显著增加了酸盐,丁酸盐和酸盐的产量.
- AZI和CIP在雄性小鼠中增加了体重,改变了血清荷尔蒙水平,并改变了血清代谢概况. 乳酸菌在暴露于AZI的雌性小鼠中的SCFA概况中发挥了关键作用.
结论:
- 暴露于微量抗生素,特别是与HFD结合,诱导显著的肠道微生物群和宿主代谢变化.
- 这些变化凸显了与环境抗生素暴露相关的潜在健康风险,特别是在敏感人群中.
- 需要进一步的研究,以充分阐明这些相互作用的长期后果和机制.
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