相关实验视频

Updated: Sep 15, 2025

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

在一次或多次剂量后,在四川大中使用difloxacin的药理动力学

Yang-Guang Jin¹, Fang Yang¹, Yu-Rong Yang²

¹College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.

Poultry science

|July 13, 2025

概括

这项研究评估了四川贝在各种剂量方案中的二素的药理动力学. 多次口服和肌内注射剂似乎有效,但单次肌内注射剂可能对某些病原体不足.

科学领域:

兽医药理学兽医药理学
野生动物医学野生动物医学
抗微生物药物的药理动力学

背景情况:

迪弗洛克萨是一种诺基诺隆抗生素,用于兽医.
了解它在诸如四川等鸟类中的药理动力学特征对于有效的治疗策略至关重要.
不同的施用途径和剂量频率可以显著影响药物的疗效.

研究的目的:

评估在单剂和多剂剂方案后在四川小鹿中使用difloxacin的药理动力学.
为了比较不同的注射途径,包括肌内注射 (IM),静脉注射 (IV) 和口服输液 (PO).
根据药理动力学参数和疗效预测,确定diloxacin在这种物种中的最佳剂量策略.

主要方法:

通过IM,IV和PO路线给四川小给予单剂和多剂量二素 (10mg/kgBW).
在48小时内采集了血液样本,并使用高性能液态染色学 (HPLC) 分析了血二素度.
药物动力学参数,包括Cmax,Tmax,生物可用性 (F),Vd和半衰期 (t1/2λz),使用非分区分析 (NCA) 计算.

主要成果:

单次使用后,口服和IM途径显示高生物利用率 (分别为96%和87.6%).
在一些组中,二素表现出广泛的分布 (Vz = 6.12 L/kg) 和缓慢的排泄 (t1/2λz 长达 10.77 小时).
多次PO和IM剂量方案,以及一次IV和PO剂量,可能对MIC ≤0.1μg/mL的病原体有效.

结论:

通过口服或肌肉内途径推给四川多个剂量方案.
对于具有较高病原体MIC值的感染,一次10mg/kg体重的肌肉内注射可能不足.
进一步的研究可能是有必要的,以完善对鸟类物种特定治疗点的剂量.

关键词:

生物可用性生物可用性迪弗洛克萨辛 (Difloxacin) 是一种药物.在HPLC中使用HPLC.药理动力学药理动力学四川小贝是什么意思四川小贝

更多相关视频

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments

Published on: May 31, 2017

相关概念视频

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...