与糖尿病相关的血 kynurenine 途径代谢物:一个横截面研究
Yingjun Mu1, Zijian Gu1, Qingyao Wang1
1School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
基努伦因途径代谢物的异常,如3-氨酸 (3-HAA) 和2-氨酸 (2-KAA),与更高的糖尿病概率有关. 相反,较高的托芬水平与成人糖尿病风险降低有关.
科学领域:
- 代谢学 代谢学 代谢学
- 三甲的新陈代谢
- 糖尿病病理生理学 糖尿病病理生理学
背景情况:
- 基努瑞宁通路 (KP) 异常与心血管疾病有关.
- 在KP代谢和糖尿病之间的关系不是很好地理解.
研究的目的:
- 在中国成年人群中调查血KP代谢物与糖尿病之间的关联.
- 探索KP失调在糖尿病发展中的作用.
主要方法:
- 对来自中国心血管疾病发病率和死亡率前性随访研究 (PFS-CMMC) 的796名成年人的二次分析.
- 使用超高性能液态染色体协同质谱测量10种血KP代谢物.
- 无条件后勤回归分析以确定赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 血中增加的3-氨酸 (3-HAA),2-氨酸 (2-KAA) 和尼古丁胺胺与糖尿病的更高几率显著相关 (P趋势<0.05).
- 较高的血托芬水平与糖尿病的几率显著降低有关 (OR:0.39,95% CI:0.21,0.72;P趋势=0.007).
- 对于kynurenine,kynurenic acid (KA),3-hydroxykynurenine (3-HK),antranilic acid (AA) 或xanthurenic acid (XA) 没有发现任何显著的关联.
结论:
- 血3-HAA,2-KAA和尼古丁胺的升高与糖尿病风险增加有关.
- 较高的托芬水平可能会对糖尿病产生保护作用.
- 这些发现表明KP代谢物在糖尿病的病理生理学中起作用.
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