在使用非侵入性产前检测和第一季度超声波的患者中,增加额透光度的患者的怀孕结果
Beatrice Bianchi1, Giulia Zaccaria1, Xin Kang1
1Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
概括
通过第一季度超声波测量部透光度 (NT) 的增加与不良结果有关. 将NT查与非侵入性产前检测 (NIPT) 结合起来,可以改善妊娠结果咨询,特别是在2.5-3.4毫米之间的NT.
科学领域:
- 产前诊断 在产前诊断.
- 孕产妇与胎儿的医学
- 遗传学 是一个遗传学.
背景情况:
- 第一个三个月的超声波上部透光度 (NT) 的增加与胎儿的遗传和先天性异常有关.
- 在非侵入性产前检测 (NIPT) 时代,NT在非侵入性产前检测 (NIPT) 中的作用受到争议,对增加NT和正常NIPT的结果的数据有限.
- 这项研究探讨了NT厚度和围产期结果之间的相关性,考虑了NIPT和超声检查的发现.
研究的目的:
- 调查NT厚度与围产期结果之间的关系.
- 评估NIPT结果对增加NT的胎儿怀孕结果的影响.
- 评估NT和NIPT在指导临床管理中的联合实用性.
主要方法:
- 从2017年8月到2023年12月,对有NT≥2.5毫米的胎儿进行了回顾性队列研究.
- 患者被分为NT组:2.5-2.9毫米,3-3.4毫米,3.5-3.9毫米和≥4毫米.
- 分析NIPT结果,侵入性遗传测试,超声检测结果和围产期结果.
主要成果:
- 在490名患者中,432人接受了NIPT,其中372人 (86.1%) 具有低风险的结果.
- 高风险NIPT发现的三发症21和18显著增加与NT (p <0.001).
- 随着NT的增加,有利的围产期结局下降;89.9%的健康新生儿的NT<3.5毫米. 对于2.5-3.4毫米的NT和正常的超声波,三位症18,13,和21发生在2%.
结论:
- 在NT测量,NIPT结果和怀孕结果之间存在强烈的关系.
- 尼普特和超声检查的结果对于辅导和管理NT增加的病例至关重要,特别是在2.5-3.4毫米之间.
- 第一个三个月的超声波和NIPT的组合为患有额头透度增加的患者提供了有价值的指导.
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