带有 pyometra 的狗的元素状态和炎症反应
Bahar Gezer Güneş1, Zeynep Günay Uçmak2, Lora Koenhemsi3
1Institute of Graduate Studies, Istanbul University-Cerrahpaşa, Istanbul 34320, Türkiye.
概括
狗皮奥美特拉与白细胞,C-反应蛋白,专蛋白和孕激素水平的改变有关. 特定的矿物不平衡,包括铜/比率,表明 pyometra 病例中的氧化应激.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 狗的健康 狗的健康
- 生物化学 生物化学
背景情况:
- 皮奥美特拉是雌性狗的严重子宫感染,以炎症和细菌存在为特征.
- 含有矿物质和微量元素的抗氧化机制在疾病过程中起着至关重要的作用.
- 了解这些机制可以帮助诊断和管理 pyometra.
研究的目的:
- 为了研究气度与各种血液学和生化标志物之间的关系.
- 评估主要矿物质 (铁,铜,,,,,) 的血清和子宫度及其比例.
- 评估这些标记物的潜力,特别是铜/的比率,作为狗pyometra中氧化应激的生物标记物.
主要方法:
- 一项涉及43只母狗的比较研究,分为对照组 (n=23) 和pyometra组 (n=20).
- 所有狗都进行了卵巢切除术,并采集了子宫内抽样以检测细菌培养.
- 血清和子宫组织的矿物质分析使用诱导合血光学发射光谱法 (ICP-OES) 进行.
主要成果:
- 皮米特拉的狗表现出白细胞计数 (WBC),单细胞与淋巴细胞比率 (MLR),中性粒细胞与淋巴细胞比率 (NLR),C反应蛋白 (CRP) 和孕激素 (P4) 水平的升高.
- 蛋白 (ALB) 水平在发育的病例中下降.
- 观察到矿物质度的显著变化,血清和子宫铜 (Cu),铁 (Fe) 和 (Mg) 的增加,而 (Se) 和 (Zn) 的减少. 在 pyometra 病例中,Cu/Zn 比率显著更高.
结论:
- 血液学和生化标志物,如CRP,WBC,MLR,NLR,P4和ALB,反映了狗体内的炎症状态和免疫状态.
- Cu,Fe,Mg,Se和Zn的血清和子宫度的变化表明它们作为pyometra中的非酶性抗氧化生物标志物的作用.
- 这项研究强调了铜/比作为一种新的氧化应激生物标志物,和其他微量元素也显示出作为非酶性抗氧化剂状态标志物的潜力.
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