相关实验视频

Updated: Sep 15, 2025

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

导航循环瘤细胞和瘤微栓塞:我们在将它们的分子动力学与临床翻译相结合时所处的位置

Deepa Bisht¹, Vivek Kumar², Sudha Gupta¹

¹Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, Uttar Pradesh 211002, India.

Biochimica et biophysica acta. Reviews on cancer

|July 13, 2025

概括

循环瘤微栓塞 (CTM) 是比循环瘤细胞 (CTC) 更强大的癌症传播指标. 先进的技术改善了CTM/CTC检测,以更好地诊断和监测癌症.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
液体活检液体活检

背景情况:

循环瘤细胞 (CTC) 和循环瘤微栓塞 (CTM) 是重要的液体活检生物标志物,表明瘤的侵入性和转移潜力.
与单个CTC相比,CTM显示出更大的异质性,可塑性,免疫逃避,茎性和转移潜力.

研究的目的:

为CTC/CTM生物学提供全面的综述.
为突出CTC/CTM的隔离和检测技术的进步.
讨论CTC/CTM在瘤学和临床管理中的作用和挑战.

主要方法:

审查微流体,纳米材料和生物传感技术在CTC/CTM隔离和检测方面的最新技术进展.
对CTC和CTM特征进行比较分析.
调查限制CTC/CTM技术临床翻译的挑战.

主要成果:

与CTC相比,CTM具有与转移和免疫逃避相关的增强特征.
高灵敏度,无标签的技术可以改善CTC/CTM的分离和分子分类.
当前的挑战包括异质性,低丰度和缺乏标准化.

结论:

集成先进的丰富和检测平台与分子分析是释放CTC/CTM潜力的关键.
CTC和CTM对实时癌症诊断,预后和治疗监测具有重大前景.
解决目前的局限性对于这些液体活检生物标志物的临床转化至关重要.

关键词:

生物标志物生物标志物循环中的瘤细胞.循环瘤的微血栓是循环的诊断诊断诊断诊断转移转移转移转移治疗方法治疗方法

更多相关视频

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

相关概念视频

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...