皇家果的神经调节作用
Feng Zhu1, Ruili Yang1, Biao He1
1School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
The Journal of nutritional biochemistry
|July 13, 2025
概括
皇家果 (RJ) 在哺乳动物和人类中表现出显著的神经调节作用,影响大脑功能,为神经系统疾病提供治疗潜力. 它的机制包括神经保护,神经炎症调节和肠-大脑轴.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 皇家果 (RJ) 是蜜蜂女王的分泌物,具有多种生物活动.
- 关于RJ对中枢神经系统 (CNS) 和相关病理的影响的了解有限.
研究的目的:
- 审查最近在哺乳动物和人类中RJ神经调节功能方面的进展.
- 总结RJ神经调节效应背后的机制.
主要方法:
- 对RJ神经调节功能和机制的现有文献的审查.
- 讨论RJ成分,如女王蜂酸 (10-HDA),主要皇家果蛋白 (MRJPs) 和微生物群.
- 对中枢神经系统功能,神经系统疾病和神经毒性事件的神经调节影响的分类.
主要成果:
- RJ成分 (10-HDA,MRJPs) 与神经保护有关.
- RJ调节神经炎症,并作为HDAC抑制剂,影响中枢神经系统的基因表达.
- 通过改变肠道微生物群的组成,RJ会影响微生物群-肠道-大脑轴.
结论:
- RJ显示了对基本的中枢神经系统功能,神经系统疾病 (AD,PD,焦虑,抑郁症) 和神经毒性事件的神经调节潜力.
- RJ的机制包括神经炎症调节,表观遗传调节 (HDAC抑制) 和微生物群-肠-大脑轴的影响.
- 需要进一步研究临床意义,表观遗传机制以及RJ在社会行为中的作用.
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