基托基纳米纤维用于乳腺癌治疗的进展:一篇综述
Guru Prasanna Sahoo1, Vineet Kumar Rai1, Deepak Pradhan1
1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
International journal of biological macromolecules
|July 13, 2025
概括
素纳米纤维为晚期乳腺癌提供了有希望的局部治疗方法,增强药物输送并减少副作用. 本综述探讨了它们在有效的癌症治疗中的潜力和挑战.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 晚期乳腺癌往往需要系统性治疗,具有显著的毒性和复发风险.
- 基于纳米纤维的局部药物输送系统为改善治疗结果提供了一种新的方法.
- 素纳米纤维由于其生物相容性,生物降解性和固有的抗癌性质,特别有希望.
研究的目的:
- 审查最近在素纳米纤维制造和乳腺癌治疗中的应用方面取得的进展.
- 探索各种酸盐纳米纤维设计,包括混合,同轴,复合和刺激响应系统.
- 突出挑战和未来的方向,以优化基托基纳米纤维在局部乳腺癌治疗.
主要方法:
- 关于用于乳腺癌的电化纳米纤维的综合文献综述.
- 分析不同纳米纤维制造技术及其治疗影响.
- 基托桑固有的抗癌活性和药物输送能力的评估.
主要成果:
- 素纳米纤维提供了高的表面积与体积比,可控制药物释放,并提高药物稳定性.
- 这些纳米纤维可以结合各种化疗剂以进行向的输送.
- 奇托桑本身具有抗血管性,抗转移性,抗炎症性和促的特性.
结论:
- 基托桑基纳米纤维代表了局部乳腺癌治疗的多功能和有效的平台.
- 进一步的研究和克服翻译障碍对于临床应用至关重要.
- 优化素纳米纤维系统具有针对性和增强性乳腺癌治疗的巨大潜力.
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