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Updated: Sep 15, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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矩阵金属蛋白酶9缺乏促进内源性心肌细胞增殖

Chenying Xiang1, Ning Liu1, Shijie Sun1

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Journal of molecular and cellular cardiology
|July 13, 2025
PubMed
概括

矩阵金属蛋白酶9 (MMP9) 缺乏会在受伤后促进新生儿心肌细胞的增殖. 这是由于代谢向糖解转移而发生的,这种转变是由乙烯基-CoA硫酶1 (ACOT1) 的上调调节介导的.

关键词:
在 ACOT1 中,ACOT1 是 ACOT1.心肌细胞的增殖和扩散在MMP9中,MMP9是MMP9.代谢重编程是一种代谢重编程.

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