自然存在的二氧化和非多环聚乙烯酸氨基醇:分布,结构多样性和生物活性
Yulin Duan1, Ying Tang2, Changxing Qi3
1Department of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan 430022, China.
Chinese journal of natural medicines
|July 13, 2025
概括
干燥和非多环聚乙烯酸 (PPAP) 是具有多样性结构和显著治疗潜力的植物化合物. 研究正在迅速扩大,揭示了癌症,炎症和神经退行性疾病的应用.
科学领域:
- 自然产品化学 自然产品化学
- 植物化学 植物化学
- 药用化学 医学化学
背景情况:
- 多环多乙烯酸葡萄醇 (PPAP) 是专门的植物代谢物,主要来自Guttiferae (Clusiaceae) 家族.
- 红色和黑色PPAP是PPAP的独特结构变体,具有广泛的研究兴趣.
- 已经确定了200多种seco-和nor-PPAP化合物,近年来发现的数量急剧增加.
研究的目的:
- 提供对天然的seco和nor-PPAP的全面审查.
- 总结它们的发生,结构多样性和生物活动.
- 突出其治疗潜力,并指导未来的研究.
主要方法:
- 在2023年6月之前对科学数据库的文献综述.
- 报告的seco-和nor-PPAP结构和隔离源的分析.
- 收集有关已识别的生物活动和治疗应用的数据.
主要成果:
- 在四个属中确定了200种seco和nor-PPAP化合物,主要是Hypericum.
- 在过去四年中发现了115种化合物,这表明研究加速.
- 化合物根据PPAP支架分为六个子组.
- 在抗癌,抗炎,抗肝保护,抗阿尔茨海默病,MDR逆转,抗抑郁,神经保护和免疫抑制应用中显示出潜力.
结论:
- 干燥和正常PPAP代表着结构多样化的自然产品的丰富来源.
- 这些化合物表现出广泛的有前途的生物活性,用于各种治疗用途.
- 为了药物开发,需要对seco-和nor-PPAP进行进一步的研究.
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
相关概念视频
01:29Biosynthesis of Lipids
98
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
98
01:26Biosynthesis of Polysaccharides
97
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
97
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
3.3K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.3K
01:28Overview of Fatty Acid Metabolism
31.7K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
31.7K
02:23Structure and Nomenclature of Alcohols and Phenols
18.3K
Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds,...
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds,...
18.3K
01:31Lipid-derived Compounds in the Human Body
5.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.4K