系统性硬化症中的心脏功能和机制:系统性审查和元分析
Mihnea Casian1,2,3, Alina Dima4,5, Ciprian Jurcuț6
1University of Medicine and Pharmacy "Carol Davila", Str. Dionisie Lupu 37, Sector 2, 020021, Bucharest, Romania. mihnea.casian@drd.umfcd.ro.
Echo research and practice
|July 13, 2025
概括
系统性硬化症 (SSc) 显著损害心脏功能,影响所有心室. 这一系统性审查突出显示,与对照组相比,SSc患者的心脏力学减弱,即使没有症状.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 系统性硬化症 (SSc) 是一种结缔组织疾病,可能涉及多个器官,包括心脏.
- 在SSc中心脏功能障碍可能是亚临床的,可能会先于明显的症状.
- 心声学,特别是组织多普勒成像 (TDI) 和斑点跟踪心声学 (STE),提供了对心脏机制的敏感测量.
研究的目的:
- 系统地评估和比较SSc患者和健康对照者之间的所有心室的常规,TDI和STE衍生的心脏参数.
- 确定SSc.中心脏参与的特定心声学标志物.
- 探索基于SSc亚型和症状状态的差异.
主要方法:
- 根据PRISMA指南进行了系统审查和元分析.
- 在MEDLINE,Scopus和Web of Science的搜索中,使用与斑点跟踪和全身性硬化症相关的关键词进行了搜索.
- 聚合分析确定了SSc患者和对照者之间的各种心声学参数的加权平均差异 (WMD),并进行了子组分析.
主要成果:
- 分析包括41项研究,包括2497例SSc病例和1439例对照.
- 在SSc患者和对照人群之间观察到TDI速度 (septal, lateral, tricuspid S'和e'波) 的显著差异.
- 在SSc患者中,STE揭示了减弱的参数,包括左心室全球纵向,周围和辐射应变,右心室应变和心房水库应变的损伤.
结论:
- 系统性硬化症与与健康个体相比,心脏功能和机制显著受损有关.
- 这些障碍在所有心室中都明显,即使没有症状或肺高血压,也可以检测到.
- 心声学参数,特别是STE衍生菌株,对于评估SSc中的心脏参与是有价值的.
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