肥胖与结直肠癌风险的关联:系统性审查
Shelby G Ziller1, Carrie S Standage-Beier2, Uzoamaka E Okwor1
1Department of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA.
Obesity (Silver Spring, Md.)
|July 14, 2025
概括
较高的体脂与增加结直肠癌 (CRC) 风险有关. 需要更多的研究来标准化肥胖度的测量,以便更好地理解这种关系.
科学领域:
- 肥胖研究的研究.
- 癌症流行病学癌症流行病学
- 代谢综合征是代谢综合征.
背景情况:
- 肥胖是一个日益严重的全球健康问题.
- 结肠直肠癌 (CRC) 仍然是全球癌症死亡的一个重要原因.
- 了解身体脂肪和CRC风险之间的联系对于公共卫生战略至关重要.
研究的目的:
- 系统地审查和评估肥胖和患结直肠癌 (CRC) 的风险之间的关联.
- 综合现有关于人体组成和事故CRC的研究证据.
- 根据测量方法和人口特征,识别CRC-脂肪性关系的潜在变化.
主要方法:
- 在主要数据库 (MEDLINE,Scopus,Embase,CINAHL,CENTRAL) 进行全面的文献搜索.
- 纳入标准侧重于评估肥胖度和成年人中发生的CRC的研究.
- 使用NIH研究质量评估工具对包含的研究进行质量评估.
主要成果:
- 10项研究中的15篇文章符合纳入标准.
- 较高的脂肪水平通常与CRC的风险增加有关.
- 关联的强度和意义因具体的脂肪度量,测量技术,瘤位置和性别而异.
结论:
- 脂肪测量技术的标准化对于跨研究的可靠比较至关重要.
- 未来的研究需要在测量精度,可访问性和成本之间取得平衡.
- 需要进一步的研究,以充分阐明脂肪和CRC风险之间的复杂关系.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
380
14:56Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
4.7K
相关概念视频
Obesity
622
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
622
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Cholesterol: Significance and Regulation
696
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
696
