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累计剂量评估与基于变压器的可变形图像记录添加用于宫癌患者的累积剂量评估

Dongdong Zhou¹, Yuheng Shao¹, Fuying Wan¹

¹Department of Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Journal of applied clinical medical physics

|July 14, 2025

概括

一种新的基于变压器的可变形图像登记 (DIR) 方法MTDIR显示,在宫癌放射治疗中,累积剂量评估的准确性得到改善. 这一进步通过为处于危险的器官提供更精确的剂量计算来提高治疗规划.

科学领域:

医学物理医学物理
放射疗法是一种放射治疗.
医疗成像医学成像

背景情况:

宫癌的治疗通常涉及内部和外部放射治疗的结合.
准确评估风险器官 (如膀和直肠) 的累积辐射剂量,对于优化治疗疗效和尽量减少毒性至关重要.
可变形图像记录 (DIR) 对于在放射治疗期间在不同时间点获得的图像进行对齐至关重要,以准确地积累剂量.

研究的目的:

开发和评估一种精确的基于变压器的可变形图像记录 (DIR) 方法,用于对宫癌患者的累积剂量评估.
将拟议的MTDIR方法的性能与现有的最先进的DIR技术 (VoxelMorph和Velocity) 进行比较.

主要方法:

对180名宫癌患者进行了回顾性分析,这些患者接受了内支臂疗法 (ICBT) 和外部光束辐射疗法 (EBRT).
提出了一种基于混合变压器结构的可变形图像注册 (MTDIR) 网络,用于注册ICBT和EBRT的CT扫描.
用直肠和膀的子相似系数 (DSC) 和豪斯多夫距离 (HD) 来评估表现. 计算和比较不同注册方法的累计剂量.

主要成果:

与Voxelmorph和Velocity相比,MTDIR方法在注册准确度方面表现优越,在不同注册阶段,在膀和直肠中实现了更高的平均DSC值.
MTDIR还表现出较低的平均豪斯多夫距离值,显示出更精确的风险器官划分.
因此,基于MTDIR的剂量增加导致了更准确的膀和直肠的累计剂量估计.

结论:

拟议的MTDIR方法为宫癌放射治疗中的可变形图像注册提供了更高的注册准确性.
这种改进的准确性转化为更可靠的累积剂量评估,可能导致更好的治疗规划和患者结果.

关键词:

宫癌:子宫癌是一种癌症.累计剂量评估累计剂量评估可变形图像的注册变形图像的注册

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