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前素和糖尿病足感染:一个元分析

Wenqiang Wang¹, Peilin Zhou¹, Xinyu Nie^1,2

¹Department of Bone and Joint Surgery (Guangxi Diabetic Foot Salvage Engineering Research Center/Research Centre for Regenerative Medicine), The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Endocrinology, diabetes & metabolism

|July 14, 2025

概括

甲素 (PCT) 是诊断糖尿病足部感染的有用标志物. 在感染患者中观察到较高的PCT水平,支持其在早期检测中的作用.

科学领域:

生物化学生物化学
临床医学临床医学
传染性疾病传染性疾病

背景情况:

甲素 (PCT) 是一种已确立的炎症标记物,用于感染诊断.
糖尿病足部感染 (DFU) 是一个重大的临床挑战.
评估PCT在诊断DFU中的实用性对于患者的治疗结果至关重要.

研究的目的:

评估血清公素 (PCT) 在诊断糖尿病脚部感染 (DFU) 中的临床效用.
进行对研究的系统审查和元分析,研究感染与非感染的糖尿病足中的PCT水平.

主要方法:

遵守PRISMA系统审查和元分析指南.
在PubMed,科学网,Embase和Cochrane图书馆进行全面的文献搜索.
包括十项研究 (六项横截面,四个队列) 涉及928名患者.
使用STATA 15.0进行统计分析,由于异质性,采用随机效应模型.

主要成果:

0.79 (95% CI: 0.43-1.14) 的综合标准化平均差异 (SMD) 表明感染糖尿病足 (IDFU) 的PCT水平明显高于未感染 (NIDFU).
观察到显著的异质性 (I2=83.6%),子组分析确定"区域"作为来源.
超回归显示BMI和HbA1c是影响异质性的重要因素 (分别为p=0.026和p=0.016).
没有发现出版偏差 (Egger的测试,p=0.680).

结论:

血清PCT水平与感染的糖尿病足有显著的相关性.
感染患者中较高的PCT水平支持其作为早期感染检测的诊断生物标志物的作用.
及时识别和治疗DFU对于降低截肢和死亡率至关重要.

关键词:

普里斯马的指导方针是什么糖尿病人的足部.感染的感染感染.炎症生物标志物炎症生物标志物这是什么意思? procalcitonin.

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Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...