木功能化益生菌用于增强抗瘤放射治疗和免疫激活
Susu Xiao1, Yuanxiang Wang2, Shulin Pan1
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, Department of Radiation Oncology and Department of Head and Neck Oncology, West China Hospital, Sichuan University, Chengdu, 610041, China. guogang@scu.edu.cn.
Journal of materials chemistry. B
|July 14, 2025
概括
一个新的生物纳米混合系统结合了细菌,石纳米颗粒和免疫激动剂,增强了对固体瘤的放射治疗. 这种方法可以改善瘤向和DNA损伤,同时保护健康的组织,显示出癌症治疗的前景.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 放射治疗 (RT) 对固体瘤至关重要,但由于DNA损伤不足和对健康组织的副作用,它面临着挑战.
- 需要下一代纳米无线电敏感剂来改善瘤的辐射敏感性并最大限度地减少附带损害.
研究的目的:
- 开发和评估一种多功能生物纳米混合疗法系统 (BPBR),用于增强癌症放射治疗.
- 为了研究结合*Bifidobacterium infantis*,石纳米颗粒和Resiquimod (R848) 与X射线照射的疗效.
主要方法:
- 构建了一个生物纳米混合系统 (BPBR),使用B. infantis用于瘤缺氧向,石纳米粒子用于增强X射线能量沉积,R848激活收费类受体7/8免疫反应.
- 将BPBR给瘤携带的小鼠,随后进行X射线照射.
- 评估了瘤生长抑制和治疗效果.
主要成果:
- *B. infantis*促进了对珠纳米粒子和R848的向向瘤部位的向输送.
- 石纳米粒子增加了X射线能量沉积和瘤内的DNA损伤.
- 结合BPBR和X射线照射,显著抑制了小鼠的瘤生长.
结论:
- 开发的生物纳米混合疗法系统 (BPBR) 有效地增强了瘤的放射敏感性,并抑制了瘤的生长.
- 该系统显示了在癌症治疗中临床翻译的潜力,并为开发新型纳米射电敏感剂提供了洞察力.
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