晚发性硬化症确实发生危机 - - 一项多中心研究
Swati Mehta1, Sumbal Wajid1, Isam Albaba2
1Albany Medical Center, Albany, NY, USA.
Arthritis care & research
|July 14, 2025
概括
晚期结核病危机 (SRC),发生在诊断后5年,影响高达25%的患者. 这种晚期SRC与早期SRC具有相似的临床特征和结果,强调无论疾病持续时间如何,都需要保持警.
科学领域:
- 类风湿病学 类风湿病学
- 腎臟病學 (nephrology) 是一種醫學.
- 系统性硬化症 系统性硬化症
背景情况:
- 结核病危机 (SRC) 传统上与早期系统性硬化症 (SSc) 诊断有关.
- 然而,SRC可以在最初的SSc诊断后多年表现出来,需要进一步调查.
研究的目的:
- 为了确定晚发SRC的患病率,临床特征和结果.
- 将这些发现与早期SRC的发现进行比较.
主要方法:
- 在1995-2018年间诊断的223名SRC患者进行了回顾性观察性研究.
- 晚期发病的SRC定义为发生在SSc诊断后5年以上.
- 提取人口统计,发病,临床特征,实验室和结果的数据;使用Pearson的千平方分析.
主要成果:
- 24.2%的SRC患者 (54/223) 患有晚期发病的SRC,平均发病时间为SSc诊断后12.2年.
- 晚期发作的SRC显示男性占主导地位,并且与早期发作的SRC相比,先前的类固醇暴露率更高.
- 在早期和晚期发病组之间,在自身抗体概况或患者结局上没有发现显著差异.
结论:
- 晚期发病的SRC占病例的很大一部分,平均在SSc诊断后12年发生.
- 早期和晚期SRC的临床特征和结果是可比的.
- 无论疾病持续时间如何,识别SRC对于优化患者的治疗结果至关重要.
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