10年来脂肪指数的变化和2型糖尿病的风险:怀特霍尔II队列研究
Cunrong Huang1, Yuntao Chen2, Annie Britton1
1Research Department of Epidemiology and Public Health, University College London, London, UK.
Diabetes, obesity & metabolism
|July 14, 2025
概括
十多年来腰围和腰与身高比的变化显著增加了2型糖尿病的风险,比英国成年人体质指数的变化更多. 监测腰围可能有助于预防糖尿病.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肥胖的评估通常使用身体质量指数 (BMI),腰围 (WC) 和腰与身高比 (WHtR).
- 了解这些肥胖指数的变化如何影响2型糖尿病等长期健康结果对于公共卫生战略至关重要.
研究的目的:
- 调查10年来英国中年成年人BMI,WC和WHtR的变化速度.
- 为了比较这三个脂肪指数的变化对患2型糖尿病的风险的影响.
主要方法:
- 利用了怀特霍尔II队列研究 (1991-2004) 中没有糖尿病的5666名参与者的数据.
- 采用线性混合效应模型来估计BMI,WC和WHtR的标准化个体变化率.
- 应用考克斯回归分析来评估肥胖指数变化率与发生型2糖尿病之间的关联,平均随访时间为17.6年.
主要成果:
- 平均年变化率为BMI的0.04 SD/年,WC的0.06 SD/年,WHtR的0.07 SD/年.
- 记录了633例发生糖尿病病例.
- 每十年WC变化增加1个SD与3.01倍的糖尿病风险相关,而WHtR变化为2.67倍,BMI变化为1.98倍.
结论:
- 十多年来腰围和腰与身高比率的变化与英国成年人体质指数的变化相比,与发生2型糖尿病的风险更为密切相关.
- 在初级保健机构中常规监测腰围可能为糖尿病预防提供更大的好处,而不是仅依靠BMI管理.
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