循环炎症蛋白调解肠道微生物群对炎症性肠病的因果作用:贝叶斯式和调解孟德尔式随机化
Zeyang Li1, Lei Jia1, Shengnan Huai2
1School of Physical Education Qilu Normal University Jinan City Shandong Province China.
FASEB bioAdvances
|July 14, 2025
概括
这项研究揭示了特定肠道细菌与炎症性肠道疾病 (IBD),克罗恩病 (CD) 和性结肠炎 (UC) 中的炎症性蛋白质之间的因果关系. 鉴定出介质17C和CD6是关键介质,为IBD提供潜在的治疗点.
科学领域:
- 胃肠道学和免疫学
- 微生物组研究 微生物组研究
- 遗传流行病学遗传流行病学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),对全球健康构成重大挑战.
- 肠道微生物群,炎症蛋白和IBD病原体之间的相互作用是公认的,但缺乏明确的因果理解.
- 现有的研究突出了相关性,但特定微生物和蛋白质因素的精确调解作用在很大程度上仍未定义.
研究的目的:
- 研究综合性肠道微生物群和循环炎症蛋白与IBD,CD和UC之间的因果关系.
- 为了确定特定的微生物种群和炎症蛋白质,因果影响IBD发展.
- 阐明炎症蛋白在因果路径中介作用,将肠道微生物群与IBD联系起来.
主要方法:
- 利用了大规模的全基因组关联研究数据,包括473个肠道微生物群,91个炎症蛋白和IBD队列 (CD和UC).
- 采用孟德尔的随机化技术,包括无变量 (UVMR) 和贝叶斯加权 (BWMR) 方法,以推断因果关系.
- 进行调解分析和灵敏度分析以量化调解效应并确认因果关系途径.
主要成果:
- 分别确定了24,20和22种肠道微生物群,对IBD,CD和UC产生显著的因果作用,区分风险和保护因素.
- 确定有3种炎症蛋白因果影响IBD,5种影响CD,5种影响UC.
- 揭示了Interleukin-17C作为对IBD和UC微生物影响的媒介,以及T细胞表面糖蛋白CD6作为对CD特定微生物影响的媒介.
结论:
- 肠道微生物群和循环炎症蛋白质是IBD病变发生的关键因素.
- 介质素-17C和T细胞表面糖蛋白CD6作为关键中间体在因果途径中出现,将肠道失调与IBD联系起来.
- 这些发现为IBD,CD和UC管理的生物标志物和潜在治疗点提供了新的见解.
更多相关视频
08:37Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
16.8K
07:34Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
2.7K
相关概念视频
01:17Irritable Bowel Syndrome I: Introduction
393
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
393
01:29Inflammatory Bowel Disease IV: Pharmacological Management
198
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
198
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
426
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
426
01:30Inflammatory Bowel Disease II: Crohn's Disease
392
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
392
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
332
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
332
01:17Chronic Bowel Disorders: Introduction
541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541