纳米医药驱动的瘤葡萄糖代谢重编程,用于增强癌症免疫治疗
Chenwei Jiang1, Minglu Tang1, Yun Su2
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Acta pharmaceutica Sinica. B
|July 14, 2025
概括
瘤重编程葡萄糖代谢,创造一种免疫抑制环境,阻碍癌症免疫治疗. 纳米药物提供了一个有希望的策略来重编程瘤葡萄糖代谢,通过克服传递和微环境挑战来提高免疫疗法的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米医学是一种纳米医学.
背景情况:
- 瘤表现出改变的葡萄糖代谢,产生乳酸盐并培养免疫抑制性瘤微环境,从而损害免疫疗法.
- 目前针对瘤葡萄糖代谢的策略在特异性,输送和克服微环境复杂性方面面临挑战,限制了临床益处.
研究的目的:
- 探索瘤葡萄糖代谢和免疫微环境之间的相互作用.
- 审查瘤葡萄糖代谢的纳米中介重编程如何可以增强癌症免疫疗法.
主要方法:
- 关于瘤葡萄糖代谢,免疫微环境和纳米医学应用的科学文献的综述.
- 分析葡萄糖代谢途径 (运输,糖解,乳酸盐) 和免疫反应之间的相互作用.
- 检查纳米医药策略的向交付和组合疗法.
主要成果:
- 瘤的葡萄糖代谢显著影响免疫微环境,促进免疫抑制.
- 纳米药物在克服输送障碍和向瘤代谢以加强免疫治疗方面显示出潜力.
- 通过纳米药物重新编程瘤葡萄糖代谢,可以重塑瘤微环境,使其更有利于免疫反应.
结论:
- 通过纳米医学调节瘤葡萄糖代谢的重编程是一种有前途的治疗策略,可以提高癌症免疫疗法的疗效.
- 解决特异性,交付和微环境复杂性的挑战对于临床翻译至关重要.
- 进一步研究基于纳米医学的代谢重编程,有可能克服免疫疗法耐药性.
更多相关视频
09:15Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
3.5K
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
1.1K
相关概念视频
01:27Tumor Immunotherapy
664
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
664
02:53Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K