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在患有多年性过敏症的患者中,以热粒素为基础的交叉反应和无症状的贝类敏感化
Moritz Maximilian Hollstein1, Marie Charlotte Schuppe1, Katharina Klara Hahn1
1Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany.
Frontiers in allergy
|July 14, 2025
概括
和虫敏感化可能导致错误的阳性贝类过敏诊断,由于交叉反应过敏原表位. 这凸显了在诊断食物过敏时需要仔细解释特定IgE (sIgE) 测试的必要性.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 在虫,和贝类蛋白质之间存在共享的过敏原表位.
- 对和贝类过敏的准确诊断需要了解IgE交叉反应性.
研究的目的:
- 评估空气过敏原-食物过敏原交叉反应的临床相关性.
- 为了确定/虫敏感性是否会增加假阳性贝类过敏测试结果.
主要方法:
- 198名患有高特异性IgE (sIgE) 的患者的横截面研究.
- 对虫,德国,,和的SIGE分析. 整体提取物.
- 在使用ImmunoCAP.AP的亚群中测量sIgE对虫热素 (Derp 10) 和鱼热素 (Pen a 1) 的测量.
主要成果:
- 患有虫敏感症的患者患喘/过敏性鼻炎的患病率更高,对和贝类的敏感性更高.
- 热菌素sIgE解释了对贝类和的sIgE变异的24-55%.
- 抗热胺sIgE与贝类和的sIgE有很强的相关性,即使在切断值以下.
结论:
- 虫敏感性与贝类无症状SIGE升高有关.
- 抗热素sIgE和sIgE对贝类/鱼的强烈相关性表明了交叉反应性.
- 研究结果表明,在虫/虫敏感个体中,可能会有广泛的假阳性贝类过敏诊断.
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