更好的魔鬼你知道:同情的鱼宿主比allopatric更好地应对一个myxozoan寄生虫
Itziar Estensoro1, Beatriz López-Gurillo1, Carolina Tafalla2
1Fish Pathology Group, Instituto de Acuicultura Torre de la Sal, Consejo Superior de Investigaciones Científicas (IATS, CSIC), Castellón, Spain.
Frontiers in cellular and infection microbiology
|July 14, 2025
概括
来自寄生虫原住民流域的钢头鱼对Ceratomyxosis表现出更强的抵抗力. 这可能是由于早期的T细胞反应,导致肠道中基于IgT的粘膜免疫反应更强.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 水生动物卫生 水生动物卫生
背景情况:
- 由Ceratonova shasta引起的切拉托米克索斯严重影响鱼,导致肠炎,出血和亡.
- 通过水传播的寄生虫阶段感染鱼并通过血液流向肠道迁移.
- 来自特有流域的钢头 (Oncorhynchus mykiss) 与来自非特有流域的 (allopatric) 相比,表现出较低的易感性.
研究的目的:
- 调查负责钢头鱼对Ceratonova shasta的不同敏感性的免疫影响因子.
- 为了比较在暴露于C. shasta基因型0.0后的同情型和全情型钢头鱼的免疫反应.
主要方法:
- 对同型和全型钢头鱼暴露于C. shasta基因型0.
- 在暴露后的多个时间点收集肠道,和血清样本.
- 免疫细胞 (Zap70+ T 细胞,IgT+ B 细胞,IgD+ B 细胞) 的量化和通过免疫组织化学评估特定的IgM存在.
- 在受感染的组织中评估寄生虫的数量和病原体学.
主要成果:
- 相似的鱼类表现出明显较低和更短时间的寄生虫负载.
- 肠道增生症在同情型鱼类中较早消失,而不是在持续存在的全情型鱼类中.
- 肠道Zap70+ T细胞的早期增加在同情鱼的IgT+ B细胞峰值之前.
- 特定的循环IgM在两组中都被检测得较晚 (57日和183日后暴露).
结论:
- 相同的钢头鱼比全方位鱼更有效地限制了肠道C. shasta的扩散.
- 对象鱼的早期T细胞反应很可能触发了肠道中基于IgT的更强的粘膜适应性免疫力.
- 晚期出现的特定循环IgM可能有助于对交和全交钢头鱼的系统性保护.
关键词:
塞拉托诺瓦沙斯塔 (Ceratonova shasta) 是一个俄罗斯的沙斯塔.在 IgD 的情况下,IgD 是在 IgT 的情况下,IgT 是 IgT.基因型 0 基因型 0肠道炎症反应 肠道炎症反应淋巴细胞 淋巴细胞特定的IgM 特定的IgM.钢头鱼株 钢头鱼株更多相关视频
09:58Environmental Screening of Aeromonas hydrophila, Mycobacterium spp., and Pseudocapillaria tomentosa in Zebrafish Systems
Published on: December 8, 2017
10.0K
13:21Establishment of Larval Zebrafish as an Animal Model to Investigate Trypanosoma cruzi Motility In Vivo
Published on: September 30, 2017
10.8K
相关概念视频
Diversity of Protists II
146
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
146
Symbiosis
30.8K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
30.8K
Hybrid Zones
20.3K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
20.3K
Formation of Species
42.5K
Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.
42.5K
Diversity of Protists I
137
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
137
Osmoregulation in Fishes
50.5K
When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
50.5K
