听觉皮层的功能以其内在的动态协作激活模式为特征,估计在个体中
M Hakonen1,2, K Lankinen1,2, P Kotlarz1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Charlestown, MA, USA.
bioRxiv : the preprint server for biology
|July 14, 2025
概括
这项研究表明,听觉皮层 (AC) 通过动态,协同激活的大脑网络发挥作用. 这些网络在休息和听觉任务期间始终存在,与听觉输入同步.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 功能神经成像 功能神经成像
背景情况:
- 由于广泛的区域响应和静态分析方法,传统方法难以绘制听觉皮层 (AC) 组织的地图.
- 大脑的动态网络组织至关重要,但在听觉皮层研究中经常被忽视.
研究的目的:
- 通过使用一种基于网络的新算法,研究听觉皮层 (AC) 内动态变化的协同激活模式.
- 通过分析休息和听觉刺激期间的动态网络活动来描述AC的功能组织.
主要方法:
- 利用高分辨率的7T fMRI数据来分析听觉皮层的局部网络协作激活模式.
- 应用了一种新的,个性化的基于网络的算法来识别可重现的动态模式.
- 检查了八个不同的交流网络模式的可重现性和个体间的变异性.
主要成果:
- 确定了一组八个可重现的动态交流协激模式,在会话之间具有很高的一致性.
- 在AC模式的发生和空间地形上显示出显著的个体间变异性.
- 在休息状态和基于任务的AC协激模式之间发现了强烈的相似之处.
- 观察到AC模式发生率和特定任务对比率之间的相关性,表明与听觉输入的同步.
结论:
- 听觉皮层功能的特点是动态变化的协同激活模式,可以在自发活动和听觉任务中观察到.
- 这些动态模式始终存在并与听觉刺激同步,为AC组织提供了新的见解.
- 这些发现支持对在AC中自发和刺激驱动的大脑活动之间的相互作用有更细致的理解.
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