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Updated: Sep 15, 2025

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通过拼接失调,TDP-43有毒的功能增益与ALS,FTD和阿尔茨海默病联系在一起

Welmoed Van Zuiden, Thea D Meimoun, Chen Bar

    bioRxiv : the preprint server for biology
    |July 14, 2025
    PubMed
    概括

    阿尔茨海默病 (AD) 中的TDP-43蛋白病理导致粉样蛋白前体蛋白 (APP) 的异常拼接,通过共享机制将AD和ALS/FTLD联系起来. 这种功能障碍是由有毒的细胞质TDP-43引起的,而不是核功能丧失.

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