没有证据表明Drosophila生殖道转录组中存在性对抗性共同进化
Rachel C Thayer1, Elizabeth S Polston1, David J Begun1
1Department of Evolution and Ecology, University of California, Davis, CA, USA.
bioRxiv : the preprint server for biology
|July 14, 2025
概括
性冲突驱动了Drosophila精液蛋白 (SFPs) 的快速进化. 然而,女性基因表达不受男性SFP变异的影响,这表明环境因素和女性遗传学,而不是性对抗,塑造了女性交配后的反应.
科学领域:
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
- 生殖生物学 生殖生物学
背景情况:
- 德罗斯菲拉精液蛋白 (SFPs) 是交叉性冲突的模型,其中男性特征进化以增加男性健康,以牺牲女性健康.
- 这种性对抗模式预测了女性的共同进化遗传路径,以应对男性驱动的SFP进化.
- SFPs的快速分子进化表明强大的选择性压力,可能与性冲突有关.
研究的目的:
- 为了测试女性在交配后的基因表达中对异性男性精液蛋白 (SFP) 表达的异性基因表达的性共同进化的预测.
- 调查生殖道和头部的女性交配后转录组是否反映男性SFP变异.
- 区分性对抗和推动女性基因表达在人口层面上的差异的替代假设.
主要方法:
- 三个Drosophila melanogaster种群的比较转录组学与不同的SFP表达.
- 分析女性在下生殖道和头部的交配后基因表达.
- 对比女性基因表达模式与男性原生种群的基因表达模式,以推断共进化的反应.
主要成果:
- 女性在交配后的基因表达没有对原始的男性群体产生显著的反应,这挑战了性对抗模式.
- 雌性交配后转录组的种群差异化更好地通过女性表达的基因型差异来解释.
- 结果支持环境变异作为男性SFP基因表达进化的驱动因素.
结论:
- 这项研究提供了证据,证明了交际性冲突在这些群体中塑造女性交配后转录组中的直接作用.
- 环境因素和女性遗传变异似乎是女性交配后基因表达差异的更重要的驱动因素,而不是男性SFP进化.
- 研究结果表明,除了性对抗之外的其他进化途径可能解释SFPs的快速分子进化.
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