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Updated: May 10, 2026

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
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Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays

Published on: January 7, 2019

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通过单细胞高含量CRISPR查,揭示跨不同遗传乱的融合细胞状态动态

Zihan Xu, Ziyu Lu, Aileen Ugurbil

    bioRxiv : the preprint server for biology
    |July 14, 2025
    PubMed
    概括

    我们开发了PerturbFate,一个新的单细胞平台,研究基因变化如何导致类似的细胞状态. 这揭示了共同的调节节点驱动细胞适应和脱差在黑色素瘤.

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    Genetic Screens02:46

    Genetic Screens

    Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
    Forward genetic screens
    Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...