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人工智能辅助的药物重定向用于人类肝纤维化

Yuan Guan1, Jakkapong Inchai1,2, Zhuoqing Fang1

  • 1Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University School of Medicine, Stanford CA.

bioRxiv : the preprint server for biology
|July 14, 2025
PubMed
概括

一位人工智能共同科学家和人类肝脏器官平台确定了新的肝纤维化治疗方法. 针对表观基因组修饰物的两种AI推药物显示出显著的抗纤维性活性,其中一种促进肝脏再生.

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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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