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横向和腹部轨道前皮层中的相反,多重信息引导大鼠的顺序食决策
Paul J Cunningham1, A David Redish2
1Department of Psychiatry, University of Minnesota, Minneapolis MN, USA.
bioRxiv : the preprint server for biology
|July 14, 2025
概括
轨道前皮层 (OFC) 使用不同的侧轨道 (LO) 和腹轨道 (VO) 区域来处理奖励价值和成本. 这些相反的信号通过代表主观的利益和机会成本来指导食决策.
科学领域:
- 神经科学是一个神经科学.
- 决策 - 决策 - 决策 - 决策
- 行为经济学是一种行为经济学.
背景情况:
- 轨道前皮层 (OFC) 对于基于价值的决策至关重要.
- OFC的不同分区,特别是中间和侧面的方面,已经知道不同的角色.
- 然而,附近的侧轨道 (LO) 和腹轨道 (VO) 亚区域之间的特定信息处理差异仍然不清楚.
研究的目的:
- 调查OFC的侧轨道 (LO) 和腹轨道 (VO) 亚区域的独特信息处理特征.
- 为了澄清LO和VO在连续的成本效益食决策中的功能异质性.
- 了解这些次区域是如何促进在食中导航权衡的.
主要方法:
- 高密度的神经记录在老鼠LO和VO亚区域进行.
- 一个神经经济学任务被用来研究成本效益的食.
- 分析神经活动与奖励遭遇阶段和决策过程相关.
主要成果:
- LO和VO对主观奖励的表现分别是利益和机会成本.
- 这些表示之间的平衡与接近或离开奖励的决定相关联.
- 在LO和VO中的不同细胞集编码了这些跨任务状态的对立表示.
- 亚区域活动与主观奖励价值的变化扩展,受外部 (稀缺) 和内部 (饥饿) 因素的影响.
结论:
- 侧面和腹部OFC编码对立的表示来指导连续的食决策.
- 在OFC内部,一个共享的编码方案将主观价值和世界状态的信息复杂化.
- 这突显了OFC内部的功能异质性,用于复杂的决策.
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