三次耐力运动强度的急性会话改变了经常炼者的皮肤下脂肪组织转录组
Cheehoon Ahn1,2, Tao Zhang1, Thomas Rode1
1Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
bioRxiv : the preprint server for biology
|July 14, 2025
概括
不同的运动强度会严重影响腹部脂肪基因表达. 高强度的运动可以促进免疫和代谢基因,而中等和低强度的运动可以促进组织修复和能量通路,从而影响长期健康.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 定期的运动训练会在脂肪组织中产生有益的适应.
- 了解脂肪组织对不同强度运动的急性分子反应对于优化运动处方至关重要.
- 腹部皮下脂肪组织 (aSAT) 在代谢健康中起着关键作用.
研究的目的:
- 为了比较低强度连续 (LOW),中等强度连续 (MOD) 和高强度间歇运动 (HIGH) 对经常炼者的aSAT转录组的急性影响.
- 为了研究基因表达模式和在不同强度的运动后aSAT中的蛋白质变化.
- 确定与心脏代谢健康相关的运动反应性基因网络.
主要方法:
- 45名经常炼的人被分配到低,MOD或高的炼课程中.
- aSAT活检是在运动前和运动后 (1.5小时) 收集的,用于批量RNA测序和蛋白质免疫测试.
- 生物信息分析包括基因组丰富,网络分析和细胞类型解.
主要成果:
- 高运动高调调节了与细胞因子分泌,胰岛素信号和蛋白质分解相关的基因.
- MOD 和 LOW 运动上调调节的基因参与了细胞外矩阵重塑,核糖体生物发生和氧化酸化.
- 血管新生,MAPK级联和时钟基因,ERK酸化和循环细胞因子的变化在所有强度上都相似.
- 网络分析揭示了与心脏代谢健康相关的运动反应性基因集群.
- 细胞类型分析显示在aSAT.内有明显的,强度依赖的反应.
结论:
- 一次单一的运动会在aSAT中诱导出明显的急性分子反应,根据强度而异.
- 在aSAT中这些早期的转录组变化是长期运动诱导适应的潜在贡献者.
- 这些发现提供了关于运动对代谢健康的益处背后的分子机制的见解.
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