白质中的单脉冲电刺激调节了人类早期视觉皮层中的iEEG视觉反应
Harvey Huang1, Kendrick N Kay2, Nicholas M Gregg3
1Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN.
bioRxiv : the preprint server for biology
|July 14, 2025
概括
单个电脉冲可以改变大脑活动. 这项研究表明,电刺激会增加宽带信号的噪音,但会放大视觉唤起的潜能,增强视觉处理.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 计算神经科学是一种神经科学.
背景情况:
- 在临床环境中,电刺激是调节大脑网络的关键工具.
- 单个电脉冲影响连接的神经元群体的确切机制尚不清楚,其中可能包括激发,抑制或噪声添加.
- 了解这些机制对于优化神经刺激疗法至关重要.
研究的目的:
- 研究单个电脉冲如何调节神经元对视觉刺激的处理.
- 为了区分电刺激与视觉处理对大脑活动的影响.
- 阐明电刺激与视觉唤起潜能之间的相互作用.
主要方法:
- 在两个人身上使用白质通道和视觉皮层中的电极利用内脑电图 (iEEG).
- 发送单个电脉冲,然后在不同的发作时间 (0,100,200毫秒) 发送视觉刺激.
- 应用有限冲动响应 (FIR) 建模来分解宽带和唤起的潜在响应到刺激和视觉诱导的组件中.
主要成果:
- 单一的电脉冲诱导了短暂的宽带增长,然后抑制,表明对宽带功率的附加效应,可能是通过噪声.
- 电刺激没有调节视觉宽带响应.
- 单个脉冲引起了不同的大脑刺激唤起的潜能和显著调节的视觉唤起的潜能,当刺激在视觉发作之前时放大它们.
结论:
- 电刺激对视觉系统处理有双重影响:对宽带功率的附加效应和视觉唤起潜力的放大.
- 单个电脉冲可以增强视觉输入的强度或同步性.
- 研究结果表明,电刺激与神经处理相互作用以调节感官输入,这对神经刺激的有效性有影响.
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