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Updated: Sep 15, 2025

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

12.7K

编程的DNA断裂驱动色素重构,并促进神经元早期反应基因的转录潜能

Lance Heady, Richard Rueda, Amir Segev

    bioRxiv : the preprint server for biology
    |July 14, 2025
    PubMed
    概括

    神经元活动通过TOP2B诱导DNA双链断裂 (DSB),增强早期反应基因转录. 重复的DSB通过改变色素相互作用来创建转录记忆.

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