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Updated: Sep 15, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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由共价逆agonist FX-909的PPARγ介导的转录抑制的结构基础

Zane T Laughlin1, Liudmyla Arifova1,2, Paola Munoz-Tello1

  • 1Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States 37232.

bioRxiv : the preprint server for biology
|July 14, 2025
PubMed
概括

新型药物FX-909通过抑制过氧酶增殖器激活受体玛 (PPARγ) 活性,有效抑制膀癌的生长. 这种化合物显示出改进的选择性和稳定转录抑制PPARγ构造.

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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
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