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血清三甲和认知衰退:研究神经退行性疾病的环境风险因素
Jianping Liu1, Sufang Wang1, Yuanying Song1
1Department of Neurology, Yancheng Third People's Hospital (The Sixth Affiliated Hospital of Nantong University, The Yancheng School of Clinical Medicine of Nanjing Medical University, The Affiliated Hospital of Jiangsu Vocational College of Medicine), Yancheng, Jiangsu, China.
Frontiers in public health
|July 14, 2025
概括
饮用水中三甲 (THM) 的较高水平与老年人的认知能力下降有关. 减少THM暴露可能有助于预防神经退行性疾病.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 三甲 (THM) 是饮用水中常见的消毒副产品,具有已知的全身毒性.
- 对于THM的神经毒性影响,特别是对认知功能的影响,尚不清楚.
- 调查THM作为神经退行性疾病的潜在环境风险因素至关重要.
研究的目的:
- 检查血清三甲 (THM) 度与老年人认知能力下降之间的关联.
- 识别可能导致认知障碍的环境神经毒素.
主要方法:
- 利用了2011-2014年国家健康和营养检查调查 (NHANES) 队列 (n=743,年龄≥60) 的数据.
- 测量了四种THM物种的血清度,并使用标准化测试 (CERAD,AFT,DSST) 评估认知功能.
- 采用多变量逻辑回归,受限立方线和子组分析来评估关联.
主要成果:
- 血清THM水平升高显著与认知障碍的可能性增加有关.
- 在最高的THM四分位数中,与最低的THM四分位数相比,认知障碍的风险增加了2.50倍.
- 在特定的THM (例如,BDCM) 和认知衰退之间观察到非线性关联,某些子组 (老年人,女性,高血压/糖尿病患者) 更容易受到影响.
结论:
- 血清THM水平与认知障碍独立相关,这表明THM作为环境神经毒剂起作用.
- 脆弱人群可能面临更高的THM诱导认知衰退的风险.
- 减少公众接触THM可能是减轻神经退行性疾病风险的策略.
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